منابع مشابه
Th-2 cytokines in allergic disease.
The description of two subtypes of T helper cells based on cytokine profiles by Mosman and Coffman in 1986 was a major step forward in thinking on control of immune responses. Building on previous divisions of responses into predominantly humoral or predominantly cellmediated, they described murine T cells clones that could be divided into either Th-1 producing IFN-y and IL-2 but not IL-4 and I...
متن کاملPivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
CD14+ peripheral blood monocytes can differentiate into fibroblast-like cells called fibrocytes, which are associated with and are at least partially responsible for wound healing and fibrosis in multiple organ systems. Signals regulating fibrocyte differentiation are poorly understood. In this study, we find that when added to human PBMCs cultured in serum-free medium, the profibrotic cytokine...
متن کاملA protease-activated pathway underlying Th cell type 2 activation and allergic lung disease.
The respiratory allergens that induce experimental Th cell type 2-dependent allergic lung inflammation may be grouped into two functional classes. One class of allergens, in this study termed type I, requires priming with adjuvants remote from the lung to overcome airway tolerogenic mechanisms that ordinarily preclude allergic responses to inhaled Ags. In contrast, the other, or type II, allerg...
متن کاملCord blood cytokines and chemokines and development of allergic disease.
Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) I...
متن کاملTh-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2000
ISSN: 0007-1420,1471-8391
DOI: 10.1258/0007142001903625